How does one get Systemic Lupus Erythematosus?

The etiology or origin of lupus is unknown, but SLE is beleived to be a disorder associated with a genetic predisposition requiring an as yet unidentified environmental trigger. The genetic risks may involve several genes including some which increase the relative likelihood of developing the disorder and others that convey a risk for more severe, such as kidney, involvement. The illness is most prevelant in African Caribbean female at about 1 in 200. However, the female offspring of a woem with the disease has about a 1 in 15 chance of developing SLE which is to say the chiold would still have an 85% chancce of never developing the disease, but because of the influence of inherited genes is still much more likely to display SLE as compared to the general population. The role for the environment is illustrated by the concordance rate of 30-50% for monozygotic or identical twins. Therefore, even between twins with identical or nearly identical DNA and genes the likelihood of the disease is great but not 100%. Multiplex registries comparing the genes between affected and unaffected members of a family where two or more persons are affected has been successful in identifying candidate genes for SLE disease causation.

Related Questions

I am still reviewing his medical reports I left of in 2002. He first started having generalized weakness, cough, vomiting and abdominal pain back in 2000. The toxicology report is still pending.

She sees a doctor every 2 months. I expressed my concern to him. He didn't think it would be a problem to have a TB test. I'm concerned.

Why are SLE lupus autoantibodies divided into organ specific and non-organ specific antibodies?

I have been diagnosed with ringworm by one doctor and diagnosed with lupus by another doctor, how can i know for sertain what i have before i take a drug that may harm me?

I am currently diagnosed with UCTD with a high probability of Lupus. No major organ involvement. For months i had a fever of 99-100 F, this eventually led to the diagnostic tests that revealed the high ANA titer, referral to Rheumatologist and diagnosis.

I am currently also dealing with colostridium difficile, or C. diff. It is exhausting to say the least.

Currently I have been off of the prescribed vancomycin for 9 days. I am having a small increase in BM and stomach bloating. I also have a 99.1-99.5F temp off and on throughout the day.

How can a physician determine if it is once again the lupus or autoimmune condition causing the raise in temp, or the c.diff?
Also, I seem to notice an increased temp during ovulation and premenstrually, would lupus have anything to do with this?
I seem to be having a hard time fighting off infection, and I imagine this too has to do with the autoimmune condition. My WBC is low (3.7)

How is lupus passed form person to person

Ask your own question!