I was diagnosed when I was 20 years old. After 2 years, I got pregnant and gave birth to a healthy baby boy. After two years I had another baby boy. I am worrying that they might get the lupus in the future. Is there any way to find out sooner to be able to prevent it. I don't want them to go through this disease

SLE is a multifactorial polygenic disorder,i.e it has both gentic and environmental causative factor...The genetic factor is contributed not by a single gene, but by a combination of many genes....Polymorphisms in the Human Leuckocyte Gene (Class I and II) genes which are clustered in chromosome 6 is the major genetic risk factor...Some of the genes currently investigated and found to be implicated/susceptible to cause SLE are PTPN22, STAT4, CDKN1A, TNFSF4 and BANK1... Chances of your children inheriting the mutant allele is <=25% but its phenotypic expresssion depends on the environmental factors and exposure (clinically known as Variable Penetrance)....Consult a genetic counsellor for thorough analysis to determine the inheritence pattern (hopefully your children might have inherited the good alleles from your partner and yourself:-))

The newest studies on SLE have found that there is a small chance that your children may have the SLE genes. So far, studies indicate that their chances are relatively small, but the studies are new, and not all is known as of yet. There are clinical trials being conducted at this time that you may be interested in becoming involved in. You may check them out at http://www.lupus.org/webmodules/webarticlesnet/templates/new_researchlfa.aspx?articleid=142&zoneid=31

Related Questions

She sees a doctor every 2 months. I expressed my concern to him. He didn't think it would be a problem to have a TB test. I'm concerned.

Why are SLE lupus autoantibodies divided into organ specific and non-organ specific antibodies?

I am currently diagnosed with UCTD with a high probability of Lupus. No major organ involvement. For months i had a fever of 99-100 F, this eventually led to the diagnostic tests that revealed the high ANA titer, referral to Rheumatologist and diagnosis.

I am currently also dealing with colostridium difficile, or C. diff. It is exhausting to say the least.

Currently I have been off of the prescribed vancomycin for 9 days. I am having a small increase in BM and stomach bloating. I also have a 99.1-99.5F temp off and on throughout the day.

How can a physician determine if it is once again the lupus or autoimmune condition causing the raise in temp, or the c.diff?
Also, I seem to notice an increased temp during ovulation and premenstrually, would lupus have anything to do with this?
I seem to be having a hard time fighting off infection, and I imagine this too has to do with the autoimmune condition. My WBC is low (3.7)

How is lupus passed form person to person

A relative of mine was diagnosed with Lupus several years ago.

I am a young female 23yr old female with Systemic Lupus...I am suffering from recurrent plueral effusions and abdominal ascites and I am not responding to oral steroids, any other treatment know?

Ask your own question!