I have got Grade IIIA lupus nephritis and received 6 cycles of two weekly treatment of 500mg of cyclophosphamide and an initial dose of 40mg prednisone daily. This was followed by 2.5g of Cellcept daily for 6 months. I did not respond to this regime, and am now on 1g pulsed cyclophos monthly for 6 months plus an initial dose 40mg oral prednisone dly. Now the physician said that I must get an additional 1g cyclo every 3 months for 2 years plus 250mg pulsed methylpred monthly. I am currently on 20mg oral pred aswell. Is it necessary for the extra IV steroids and if so, what oral dose of prednisone sgould I be on, and would oral methylprednisone not be better that prednisone? IE Wich one has less side effects such a Cushings etc?
Approximately half of ISN TYPE III lupus nephritis develop nephrotic syndrome in 2 years.and most dervelop hypertension. if untreated most develop End Stage Renal Disease in 2 years. this is the reason why your doctor is putting you on high dose steroids and cytotoxic drugs that cause immunosuppression. such an aggressive therapy is reccomented.
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