I have been followed by a rheumatologist for the last 4 years for arthritis/arthralgias. I have also had problems with skin rashes, sun sensitivity, dry mouth and eyes and have tested positive on ANA (1:1280), SSA (high titer), Lupus anticoagulant and anti-cardiolipin antibodies, elevated sed rate. My SSA just came back positive this summer for the first time. Prior to that I was diagnosed with Sjogren's syndrome, but now wonder if Lupus is in the works. Is this possible after so many years?

sorry2 know u r in Real serious problem.
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God Bless u.

Your symptoms does not completely suggests of SLE. It will be better if you could do an ANA profile + anti dsDNA and antiRo serum tested.
ANA test is positive for more than 95% of SLE cases. ANA negative lupus is very rare , such patients have positive anti ds.DNA or anti Ro . If all the above are negative lupus can be ruled out. . But in many cases these tests get positive about one to two years after onset of symptoms. Hence testing has to be repeated, to confirmly rule out lupus.
Thank you.

DIAGNOSTIC CRITERIA FOR SLE
1.malar or discoid rash . Reddish raised patches over the cheeks.
2.photosensitivity. Exposure to uv light causes rash
3.oral and nasal ulcers
4.tenderness and swelling of two or more joints.
5.pleuritis of lung
Pericarditis of heart
6.urine protein of more than 0.5 g /dl
7.seizures or psychosis without other causes.
8.anemia.or decreased white blood cells.
9.anti.dsDNA, anti Sm, anti phospholipid
10. Abnormal ANA levels.
Such skin lesions can be called discoid lesions. they appear in about 5 to20 % of lupus patients.
they can appear as red scaly patches, severe itching, bullae.
treatment with topical application of glucocorticoics can help a lot.
in patiets with severe bl;eeding lesions i would suggest a blood platelet count. reduction in count is associated with manifestaions in some and requires high dose prednisolone therapy.A peripheral smear should also be done to rule out any haemolysis.
thank you

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