Hives known medically as urticaria often are idiopathic which means of unkown origin. On the other hand, sometimes they are a manifestation of allergy to food or medication. Persons with lupus occasionally experience hives which may result from mast cell release of histamine or the generation by immune complexes of complement degradation products, such as C3a and C5a, which can serve as anaphylatoxins that increase the permeability of blood vessels leading to swelling or edema in the skin, which is to say hives.
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